Study of Vitreoretinal Interface Abnormalities In Patients With Pseudoexfoliation Syndrome

Evaluating vitreoretinal interface (VRI) abnormalities in patients with pseudoexfoliation syndrome (PEX). In this prospective cross-sectional study (case-control design), the research sample included 67 participants (80 eyes). The control group consisted of 40 participants (40 eyes) who were ophthalmic clinic attendees without pseudoexfoliation syndrome, and their right eyes were selected for comparison with the case group. The case group included 27 patients (40 eyes) with PEX who were examined at the ophthalmology clinic at Latakia University Hospital in Lattakia during the period 2024–2025, and who met the study’s inclusion criteria. A detailed medical history was taken, including measurement of distance visual acuity and BCVA, Amsler grid test, slit-lamp examination, fundus examination, gonioscopy, intraocular pressure measurement using a Goldman tonometer, visual field testing, and OCT evaluation of the vitreoretinal interface. PEX patients were categorized by pseudoexfoliation severity into three groups (mild, moderate, severe). Rate of PVD, Partial PVD and ERM were more common in PEX group, whereas absence of PVD was more common in control group, with statistically significant differences. Complete PVD was more frequent in control group, but the difference was not statistically significant. There was a statistically significant association between ERM and PVD in PEX group as ERM was observed only in eyes with PVD. There was a statistically significant association between severity of PEX and both PVD and ERM rates in PEX group with their rates increases as the severity of PEX increases. Patients with pseudoexfoliation syndrome show higher rates of vitreoretinal interface abnormalities, which increase with more PEX severity.