Effect of serum LDH and CK levels on condition and prognosis of COVID-19 patients

To explore the factors affecting the condition and prognosis of COVID-19. The clinical data of 228 patients with COVID-19 diagnosed in Renmin Hospital of Wuhan University from January 15 to March 1, 2020 were collected. The relationship between the levels of serum lactate dehydrogenase(LDH)/creatine kinase(CK) and the condition/prognosis of these patients were retrospectively analyzed. The levels of serum LDH/CK in male patients with COVID-19 were significantly higher than those in female patients, and increased with age; more importantly, the levels of serum LDH and CK in severe group were significantly higher than those in non-severe group(P<0. 05); LDH and CK levels were related to the overall survival(OS) of COVID-19 patients. The OS of LDH increasing group was lower than that of normal LDH+CK group, and OS of LDH+CK increasing group was lower than that of LDH increasing group. The increase of LDH and CK can reduce the overall survival of COVID-19 patients, and serum LDH and CK levels can be used as risk factors to predict the progression of the disease.