Effect Of Omega-3 Fatty Acid Supplementation on Oxidized LDL In Health Science Obese Students

Excess body weight is strongly associated with increased oxidized low-density lipoprotein (LDL), a marker of atherosclerotic progression and cardiovascular risk. Omega-3 fatty acids possess antioxidant and lipid-lowering properties, yet their effects on oxidized LDL in obese young populations remain underexplored. This study evaluated the impact of omega-3 supplementation on oxidized LDL and related metabolic parameters among obese adolescents and young adults. A four-week clinical trial was conducted involving 34 female participants aged 17–20 years with a body mass index above 25 kg/m². The intervention group received 1200 mg of omega-3 fatty acids daily, while the control group received nutritional counseling. After four weeks, omega-3 supplementation resulted in a significant decline in oxidized LDL levels (p < 0.05) compared to the control group. Improvements were also observed in anthropometric and metabolic parameters, including reductions in body weight, waist circumference, visceral fat, and key lipid markers such as total cholesterol and LDL-C. These findings indicate that short-term omega-3 supplementation can beneficially influence oxidative and metabolic profiles in young obese individuals, underscoring its potential role in early cardiovascular risk reduction and metabolic health optimization.