Dendritic Fibromyxolipoma is a Benign Variant of Spindle Cell Lipoma That can Potentially Mimic Malignancy

Dendritic fibromyxolipoma is a rare soft tissue tumor that commonly occurs in the superficial fascia of the head and neck region, chest wall, and shoulder. It is composed of stellate cells with dendritic processes within an extensive myxoid background. This study aims to analyze the histopathological characteristics and differential diagnosis of dendritic fibromyxolipoma, highlighting the role of ancillary investigations in establishing an accurate diagnosis. A literature search was conducted on PubMed and ScienceDirect on 2 January 2026. Relevant articles reporting cases of Dendritic fibromyxolipoma with available clinical and pathological descriptions were included. This paper highlights the histopathological features and ancillary investigations used to achieve an accurate diagnosis, thereby assisting pathologists in establishing the correct diagnosis and ensuring optimal patient management and outcomes. The current study reviews all reported cases of dendritic fibromyxolipoma indexed in the PubMed, Scopus, and ScienceDirect databases published in English language. Dendritic fibromyxolipoma is a relatively uncommon benign adipocytic neoplasm that can closely mimic many malignant tumors. This review paper presents the clinical presentation, histopathological findings, and ancillary investigations of dendritic fibromyxolipoma.