Association between Triglyceride–Glucose Index and Lipid Ratio with Non-alcoholic Fatty Liver Disease in Type 2 Diabetes Mellitus Patients

Glucose and lipid metabolism are closely related to NAFLD. In previous study showed that TyG index has been recommended as a reliable and simple indicator to identify individuals for the risk of NAFLD. In addition, evidence showing the relationship between the TG/HDL-chol ratio and the LDL/HDL-chol ratio with NAFLD is still very limited. Considering the high prevalence and risk of NAFLD in T2DM, this study aims to evaluate association between Triglyceride–glucose Index and Lipid Ratio with NAFLD in T2DM patients. This analytical observational study employed a cross-sectional design and was conducted on T2DM patients aged 18 years and older in Wahidin Sudirohusodo hospital, Makassar, Indonesia. Statistical analysis was performed using the Independent T test and Mann-Whitney test with a significance level of p < 0.05. A total of 149 T2DM subjects, consist of 82 with NAFLD (55%) and 67 without NALFD (45%) were included. Our study found a significant association between Tyg index value and NAFLD in T2DM patients with p = 0.020. We also found a significant association between TG/HDL ratio value with NAFLD (p = 0.047) meanwhile there is no significant relationship between the LDL/HDL ratio value with NAFLD in T2DM patients (p = 0.646). We concluded that there are association between the Tyg Index and the TG/HDL ratio with NAFLD in T2DM patients.