Association Between Remnant Cholesterol And Insulin Resistance With Metabolic-Associated Fatty Liver Disease (MAFLD) : Mini Review

Globally, the incidence of Metabolic Associated Fatty Liver Disease (MAFLD) has significantly grown due to the prevalence of obesity and rising consumption of refined carbohydrates and saturated fats. Numerous metabolic issues are largely caused by insulin resistance (IR), a condition in which the body's cells react poorly to the hormone insulin. Hepatic steatosis, or increased fat synthesis and storage in the liver, is a result of IR's alteration of normal glucose and lipid metabolism. Remnant cholesterol is increasingly recognized for its role in promoting liver inflammation in metabolic-associated fatty liver disease (MAFLD). The molecular mechanisms linking RC to liver inflammation involve several interconnected pathways including insulin resistance, lipoprotein metabolism and impaired hepatic lipid metabolism.